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Jaakko Perheentupa Selected Research

Autoimmune Polyendocrinopathies (Schmidt Syndrome)

10/2013BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease.
8/2011IL-7 dysregulation and loss of CD8+ T cell homeostasis in the monogenic human disease autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.
2/2010Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines.
12/2009Candida albicans isolates from APECED patients show decreased susceptibility to miconazole.
3/2009Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems.
10/2008Activity of amphotericin B, anidulafungin, caspofungin, micafungin, posaconazole, and voriconazole against Candida albicans with decreased susceptibility to fluconazole from APECED patients on long-term azole treatment of chronic mucocutaneous candidiasis.
10/2008Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes.
3/2008Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen.
1/2008Reduction of fluconazole susceptibility of Candida albicans in APECED patients due to long-term use of ketoconazole and miconazole.
10/2007Decreased susceptibility of Candida albicans to azole antifungals: a complication of long-term treatment in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients.
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Jaakko Perheentupa Research Topics

Disease

16Autoimmune Polyendocrinopathies (Schmidt Syndrome)
10/2013 - 01/2002
12type 1 Autoimmune polyendocrinopathy syndrome
06/2017 - 04/2003
3Autoimmune Diseases (Autoimmune Disease)
10/2013 - 04/2004
3Chronic Mucocutaneous Candidiasis
01/2011 - 10/2008
3Addison Disease (Addison's Disease)
01/2008 - 06/2002
3Type 1 Diabetes Mellitus (Autoimmune Diabetes)
12/2005 - 06/2002
2Interstitial Nephritis (Tubulointerstitial Nephritis)
10/2016 - 08/2006
2Candidiasis (Moniliasis)
08/2011 - 07/2006
2Hypoparathyroidism
03/2008 - 02/2004
2Hypogonadism (Hypergonadotropic Hypogonadism)
01/2008 - 02/2004
1Chronic Kidney Failure (Chronic Renal Failure)
10/2016
1Male Infertility (Male Sterility)
06/2015
1Connective Tissue Diseases (Connective Tissue Disease)
10/2013
1Interstitial Lung Diseases (Interstitial Lung Disease)
10/2013
1Thymoma (Thymic Carcinoma)
02/2010
1Airway Obstruction (Choking)
03/2009
1Cerebellar Ataxia (Dysmetria)
03/2009
1Stiff-Person Syndrome (Stiff Man Syndrome)
03/2009
1Splenomegaly
11/2008
1Marginal Zone B-Cell Lymphoma (MALT Lymphoma)
11/2008
1Hypopituitarism (Sheehan's Syndrome)
01/2007
1Esophageal Squamous Cell Carcinoma
08/2006
1Infections
07/2006
1Heart Failure
06/2003
1Constrictive Pericarditis
06/2003
1Heart Diseases (Heart Disease)
06/2003
1Alopecia (Baldness)
06/2002

Drug/Important Bio-Agent (IBA)

18AutoantibodiesIBA
10/2016 - 01/2002
7AutoantigensIBA
06/2017 - 02/2004
4AntibodiesIBA
10/2008 - 04/2003
3Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA
03/2009 - 04/2003
2Proteins (Proteins, Gene)FDA Link
10/2013 - 02/2004
2Interleukin-17 (Interleukin 17)IBA
01/2011 - 02/2010
2CytokinesIBA
01/2011 - 02/2010
2AntigensIBA
02/2010 - 04/2003
2Miconazole (Monistat)FDA LinkGeneric
12/2009 - 01/2008
2Aromatic-L-Amino-Acid DecarboxylasesIBA
03/2009 - 04/2003
2Neurotransmitter Agents (Neurotransmitter)IBA
03/2009 - 04/2003
2AzolesIBA
10/2008 - 10/2007
2Fluconazole (Zonal)FDA LinkGeneric
10/2008 - 01/2008
2InterferonsIBA
10/2008 - 07/2006
2EpitopesIBA
12/2005 - 01/2002
2Pyridoxal Phosphate (Pyridoxal 5 Phosphate)IBA
04/2004 - 04/2003
2EnzymesIBA
04/2004 - 04/2003
1Endothelins (Endothelin)IBA
06/2017
1Aquaporins (Water Channels)IBA
10/2016
1transglutaminase 4IBA
06/2015
1Interleukin-7 (Interleukin 7)IBA
08/2011
1Interleukin-22 (IL-22)IBA
02/2010
1Potassium Channels (Potassium Channel)IBA
03/2009
1Coloring Agents (Dyes)IBA
03/2009
1gamma-Aminobutyric Acid (GABA)IBA
03/2009
1Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
03/2009
1Tryptophan HydroxylaseIBA
03/2009
1Voriconazole (Vfend)FDA LinkGeneric
10/2008
1posaconazoleFDA Link
10/2008
1Caspofungin (Cancidas)FDA Link
10/2008
1Micafungin (FK463)FDA Link
10/2008
1AnidulafunginFDA Link
10/2008
1Amphotericin B (Amphotericin)FDA LinkGeneric
10/2008
1Pharmaceutical PreparationsIBA
10/2008
1Complementary DNA (cDNA)IBA
03/2008
1Leucine-Rich Repeat ProteinsIBA
03/2008
1Ketoconazole (Nizoral)FDA LinkGeneric
01/2008
1Phosphopyruvate Hydratase (Enolase)IBA
01/2007
1MineralocorticoidsIBA
08/2006
1Immunoglobulin G (IgG)IBA
12/2005
1Protein Isoforms (Isoforms)IBA
04/2004
1Amino AcidsFDA Link
04/2004
1sulfoalanine decarboxylaseIBA
04/2004
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
02/2004
1Tyrosine (L-Tyrosine)FDA Link
02/2004
1Steroid 21-Hydroxylase (21 Hydroxylase)IBA
02/2004
1ORALIT (ORS)IBA
02/2004
1Histidine DecarboxylaseIBA
04/2003
1HLA-DRB1 Chains (HLA DRB1)IBA
06/2002
1HLA-DRB1*04 antigenIBA
06/2002
1HLA Antigens (Human Leukocyte Antigens)IBA
06/2002
1Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
01/2002
1Cholesterol Side-Chain Cleavage Enzyme (CYP11A1)IBA
01/2002

Therapy/Procedure

1Pericardiectomy
06/2003
1Therapeutics
06/2002